ION-ZC1 Antimicrobial Study 3 - MRSA in Biofilm


Study Title: ION-ZC1 Antimicrobial Study 3 - MRSA in Biofilm

Author: INDEVION Biotechnology Research and Development Ltd. Principal Investigator Dr. Zsolt Keresztessy, Ph.D. (2017).

Methods: ION-ZC1 antimicrobial study report 3 evaluating MRSA in biofilm assays using the microtiter plate sensitivity method. The study design will provide information on MRSA under biofilm conditions. The anti-biofilm activity of ION-ZC1 was evaluated by the crystal violet assay published by O'Toole (2011). The study was conducted against three methicillin-resistant Staphylococcus aureus isolates.

Results: Minimum inhibitory concentrations (MIC) were determined after 24 hours in which a prominent decrease (50%) of the biofilm mass was observed. Isolates of Staphylococcus aureus (MRSA). The degree of inhibition of biofilm mass at 6.5%, 12.5%, 25% and 50% ION-ZC1 in Staphylococcus aureus isolates 22953, 22580 and 21795 were in the range of 5% (v/v) to 38% (v/v), averaging each of the three groups isolated provides a CIM value of inhibition at each concentration of 5%, 11%, 14% and 29% (v/v) in vitro.

Conclusions: On average at least 50% inhibition was detected on biofilm reduction in 24 hours. Future studies over a longer period of time may determine increased MRSA inhibition in biofilm as shown in the positive results of Study 2 (MRSA in non-biofilm conditions). ION-ZC1 shows promising in vitro results in a wide range of gram-negative and gram-positive bacteria and multiple species of fungi. ION-ZC1 in vitro can reduce biofilm mass and cause MRSA cell death.

Full Study English Full Study Spanish
Ion Biotechnology México S.A. de C.V.
Plaza Marina Local D24
Puerto Vallarta
Jalisco, Mexico
Mon - Fri: 9:00 am to 6:00 pm CST.
Saturday - Sunday: Closed.
Phone Numbers
MX: +52 (322) 221-1057
USA: +1 (866) 333-7689
Report an adverse event
© 2024 Copyright - Ion Gel ZCM-25® 2+Cations® All Rights Reserved Ion Biotechnology México, S.A. de C.V.