In a preclinical study completed in November 2023, led by Dr. José Trinidad Pérez Urizar, Ph.D., a professor in the Biomedical Sciences Department of the University of San Luis Potosí, the objective was to assess the systemic bioavailability of the metal ions—Magnesium (Mg+2), Zinc (Zn+2), and Copper (Cu+2)—contained in the active ingredient ION-ZCM1 (solution) and Ion Gel ZCM-25®. Both injectable and topical protocols were administered in single and multiple doses in experimental models, using 160 mice and 10 rabbits.
The results from topical application of Ion Gel ZCM-25® in rabbits demonstrated high bioavailability of the Magnesium, Zinc, and Copper cations in the bloodstream, showing systemic absorption within the first hour of application. This finding underscores the antioxidant topical gel's effectiveness in delivering essential ions through the skin barrier.
Additionally, the pharmacokinetic profile of this study revealed no accumulation of metal ions, indicating a safe profile regarding cellular toxicity. This provides important data supporting the topical gel’s safety in long-term applications.
The study also highlighted the antioxidant capacity of Ion Gel ZCM-25®. Its antioxidant index (FRAP) after a single dose (401,793) and double doses (414,816) surpassed the control (386,496), confirming its high reducing capacity through electron transfer within the first hours of application. These results reinforce the gel's role as a topical antioxidant solution for reducing oxidative stress and supporting cellular health.
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