Preclinical Study PK & Oxidative Stress Reduction

In a preclinical study completed in November of 2023 by Dr. José Trinidad Pérez Urizar, Ph.D. a professor in the Biomedical Sciences Department of the University of San Luis Potosí. The preclinical study’s objective was to characterize the systemic bioavailability of the metal ions - Magnesium (Mg+2), Zinc (Zn+2), and Copper (Cu+2) contained in the active ingredient ION-ZCM1 (solution) and Ion Gel ZCM-25®. Injectable and topical protocols were administered in single and multiple doses in experimental models, using 160 mice and 10 rabbits.

The results obtained in rabbits after topical application of Ion Gel ZCM-25® indicate a high bioavailability of the Magnesium (Mg+2), Zinc (Zn+2), and Copper (Cu+2) cations in the blood, showing a systemic absorption in the first hour of application.

Additionally, the pharmacokinetic profile of this study indicated that there is no accumulation of the metal ions. This is relevant data regarding cellular toxicity, establishing a safe pharmacokinetic profile over the study period.

The results obtained on the topical application of Ion Gel ZCM-25® as its antioxidant capacity (FRAP) after a single dose (401,793)  and double doses (414,816) in terms of the antioxidant index were higher than the control (386,496), confirming its high reducing capacity by electron transfer in the first hours of application. 

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