Assessment of the Antifungal Efficacy of Ion Gel ZCM-25® Against Candida auris

Background: Candida auris is an emerging fungal pathogen known for its resistance to conventional antifungal treatments. It is associated with high morbidity and mortality rates, particularly in healthcare environments. The development and evaluation of novel antifungal agents capable of effectively combating Candida auris are imperative.

Objective: This study sought to investigate the antifungal activity of Ion Gel ZCM-25® against Candida auris MYA-5001™strain, utilizing the methodological framework established by the Mexican Standard NMX-BB-040-SCFI-1999 to evaluate germicidal products.

Methods: The antifungal potential of Ion Gel ZCM-25® was quantified through a controlled assay, wherein a specified inoculum of Candida auris (expressed in Colony Forming Units per milliliter, CFU/mL) was introduced to 100 g of the antifungal gel. The reduction in fungal viability was measured at intervals of 30 seconds, 60 seconds, and 10 minutes post-exposure.

Results: Application of Ion Gel ZCM-25® demonstrated a marked reduction in the viability of Candida auris, with percentage reductions of 55.9% at 30 seconds, 63.6% at 60 seconds, and 92.3% after 10 minutes of exposure. These findings indicate a time-dependent increase in antifungal activity.

Conclusion: Ion Gel ZCM-25® exhibits significant antifungal properties against Candida auris, suggesting its potential utility as an effective antifungal topical gel. This study supports the further investigation of Ion Gel ZCM-25® for its broader antifungal efficacy and potential incorporation into infection control and treatment strategies against drug-resistant fungal pathogens.

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