Candida auris is an emerging fungal pathogen known for its resistance to conventional antifungal treatments, often resulting in high morbidity and mortality rates, especially in healthcare environments. The development and evaluation of novel antifungal agents, such as Ion Gel ZCM-25®, are essential for effectively combating Candida auris infections and enhancing infection control.
This study sought to investigate the antifungal activity of Ion Gel ZCM-25® against the Candida auris MYA-5001™ strain, utilizing the methodological framework established by the Mexican Standard NMX-BB-040-SCFI-1999 for evaluating germicidal products. This research underscores the potential role of this antifungal topical gel in managing drug-resistant fungal pathogens.
The antifungal potential of Ion Gel ZCM-25® was quantified through a controlled assay, wherein a specified inoculum of Candida auris (expressed in Colony Forming Units per milliliter, CFU/mL) was introduced to a 100 g sample of the antifungal gel. Fungal viability reduction was measured at intervals of 30 seconds, 60 seconds, and 10 minutes post-exposure, highlighting the gel's rapid antifungal action in reducing fungal presence on contact.
The application of Ion Gel ZCM-25® demonstrated a marked reduction in the viability of Candida auris, with percentage reductions of 55.9% at 30 seconds, 63.6% at 60 seconds, and 92.3% after 10 minutes of exposure. These findings indicate a time-dependent increase in antifungal activity, supporting the gel’s efficacy in infection control and antifungal treatment strategies.
Ion Gel ZCM-25® exhibits significant antifungal properties against Candida auris, suggesting its potential utility as an effective antifungal topical gel. This study supports further investigation into Ion Gel ZCM-25® for broader antifungal efficacy and its incorporation into infection control and treatment protocols, particularly for drug-resistant fungal pathogens.
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