Efficacy of Ion Gel ZCM-25® in the Antimicrobial Treatment Against Acinetobacter baumannii

Background: Acinetobacter baumannii is a pathogenic bacterium responsible for a range of infections, particularly in healthcare settings, posing significant treatment challenges. The need for effective antimicrobial agents against Acinetobacter baumannii is critical. Ion Gel ZCM-25® represents a novel antimicrobial topical gel formulated to combat such pathogens.

Objective: This study aimed to evaluate the antimicrobial activity of Ion Gel ZCM-25® against the Acinetobacter baumannii BAA-1790™ strain, adhering to the standards outlined in the Mexican Standard NMX-BB-040-SCFI-1999 for germicidal product evaluation.

Methods: A quantitative assay was conducted using a defined inoculum concentration of Acinetobacter baumannii, which was applied to 100 g of Ion Gel ZCM-25®. The antimicrobial efficacy was quantified by calculating the percentage reduction in Colony Forming Units per milliliter (CFU/mL) at specified time intervals (30 seconds, 60 seconds, and 10 minutes) post-application.

Results: The application of Ion Gel ZCM-25® demonstrated significant antimicrobial activity against Acinetobacter baumannii. The bacterial load was reduced by 87.0% within the first 30 seconds, escalating to 93.0% by the 60-second mark and peaking at 93.5% after 10 minutes of exposure.

Conclusion: Ion Gel ZCM-25® exhibits potent antimicrobial properties against Acinetobacter baumannii, highlighting its potential as an effective topical antimicrobial agent in healthcare settings and broader clinical applications.

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